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Journal

  1. Tsai-Ling Li, Meng-Wei Wu, Chian-Hui Lai, Yu-Hsuan Chang, Li-Jen Su, Wen-Yih Chen “Designed phosphate-methylated oligonucleotides as PCR primers for SNP discrimination” Analytical Biochemistry (Accepted) (2019)

  2. Vaida Paketuryte, Vaida Linkuviene, Georg Krainer, Wen-Yih Chen and Daumantas Matulis “Repeatability, precision, and accuracy of the enthalpies and Gibbs energies of a protein-ligand binding reaction measured by isothermal titration calorimetry” European Biophysics Journal  (https://doi.org/10.1007/s00249-018-1341-z) (2018)

  3. Tai-Chi Kuo, Yu-Chiang Huang, Daumantas Matulis and Wen-Yih Chen* “Molecular Self-Interactions of Ribonuclease A Revealed by Isothermal Titration Calorimetry and Self-Interaction Chromatography - Effects of Anisotropy of Protein Surface Charge” Journal of the Taiwan Institute of Chemical Engineers (https://doi.org/10.1016/j.jtice.2018.12.008 (2018)

  4. Lina Baranauskiene, Tai-Chih Kuo, Wen-Yih Chen* and Daumantas Matulis “Isothermal titration calorimetry for characterization of recombinant protein” Current Opinion in Biotechnology, 55, 9-15 (2018) (IF: 8.330) (5/407: Biomedical Engineering)

  5. CJ Huang, ZE Lin, YS Yang, H W-H Chan, W.-Y. Chen* “Neutralized Chimeric DNA Probe for Detection of Single Nucleotide Polymorphism on Surface Plasmon Resonance Biosensor” Biosensors and Bioelectronic 99, 170-175 (2018) (IF:7.78) (2/76: Chemistry, Analytical)

  6. WP Hu, CC Tsai, YS Yang, H W-H Chan and WY Chen* “Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as probe” Scientific Reports (2018) 8:12598 (IF:4.122) (12/64: Multi-disciplinary Science)

  7. Hui-Ting Lin, Wei Yang, Wen-Yu Su, Chun-Ju Chan, Wen-Yih Chen, Jeffrey J. P. Tasi and Wen-Pin Hu “Study on the Binding Ability of Truncated Aptamers for the Prostate Specific Antigen Using Both Computational and Experimental Approaches” FC 2017, LNEE 464, pp. 46–55, (2018) (https://doi.org/10.1007/978-981-10-7398-4_5)

  8. Pi-Chou Hsieh, Hui-Ting Lin, Wen-Yih Chen, Heffrey J.P. Tsai and Wen-Pin Hu “The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen” BioMed Research International, doi.org/10.1155/2017/5041683 (2017

  9. Vaida Linkuviene, Georg Kranier, Wen-Yih Chen and Daumantas Matulis “Isothermal titration calorimetry for drug design:  Precision of enthalpy and binding constant easurements and comparison of the instruments” Analytical Biochemistry 515, 61-64 (2016)

  10. Tzu-Cheng Sung, Wen-Yih Chen, Pramod Shah and Chien-Sheng Chen “Replaceable liposomal aptamer for the ultrasensitive and rapid detection of biotin” Scientific Report. DOI:0.1038/srep21369 (2016)

  11. Tai-Chih Kuo, Ching-Wei Tsai, Peng-Chen Lee, Wen-Yih Chen* “Revisiting the streptavidin–biotin binding by using an aptamer and displacement isothermal calorimetry titration” J. Mol. Recog. 28, 125-128 (2015)

  12. CW Tsai, WW Hu, CI Liu, RC Ruaan, BC Tsai, SL Jin, Y Chang, WY Chen* “The consideration of Indolicidin modification to balance its hemocompatibility and delivery efficiency” International Journal of Pharmaceutics 494(1) 498-505 (2015)

  13. WP Hu, J V Kumar; CJ Huang, WY Chen* “Computational selection of RNA aptamers against angiopoietin-2 and experimental evaluation” Biochemical and Biomedical Research International, 1-8, (2015)

  14. SB Yeh, Chien-Sheng Chen, Wen-Yih Chen*, and Chun-Jen Huang* “Modification of Silicone Elastomer with Zwitterionic Silane for Durable Antifouling Properties” Langmuir 30 (38), 11386-11393 (2014)

  15. Chih-Ying Liu, Xin Li, Wen-Yih Chen, Li-Chiao Chang, Yi-Fan Chen, Hsin-Lung Chen, Ya-Sen Sun, Hsiu-Yun Lai, E-Wen Huang, “PEGylation Site-dependent Structural-heterogeneity Study of MonoPEGylated Human Parathyroid Hormone Fragment hPTH(1-34)” Langmuir 30(38), 11421-11427 (2014)

  16. SF Lin, FC Chang, ZH Chen, CM Wang, TH Yang, WY Chen* and JY Chang* “A polarization control system for intensity-resolved guided mode resonance sensors” Sensors, 14(3), 5198-5206 (2014)

  17. CW Tsai, SL Jheng, WY Chen* and RC Ruaan* “Strategy of Fc-Recognizable Peptide Ligand Design for Oriented Immobilization of Antibody” Analytical Chemistry 86(6), 2931-2938 (2014)

  18. SK Chen, CA Chung, YC Cheng, CJ Huang, WY Chen, RC Ruaan, C Li, CW Tsao, WW Hu, and CC Chien “Toll-like Receptor 6 and Connective Tissue Growth Factor are significantly upregulated in mitomycin-C treated urothelial carcinoma cells under hydrostatic pressure stimulation” Genetic Testing and Molecular Biomarkers, 18(6), 410-416 (2014)

  19. Hu WP, Huang LY and Chen WY* “Optimal Buffer pH Value on the Detection of HAS by using a Protein Chip Prepared by DNA-directed Immobilization” Applied Mechanics and Materials, 284-287, 398-402 (2013)

  20. Chen WY*, Hsu MY, Tasi CW, Ruaan RC, Kao WH, Chung Chuan HYT “Kosmotrope-like Hydration behavior of Polyethylene Glycol- Evidences of Microcalorimetry and Binding Isotherm Measurements” Langmuir, 2;29(13) 4259-65 (2013)

  21. Chen WY*, Chen HC, Yang YS, Huang CJ, and Hu WP “Improved DNA detection by utilizing electrically neutral DNA probe in field-effect transistor measurement as evidence by surface plasmon resonsnce imaging” Biosensors and Bioelectronics 41,795-801 (2013)

  22. Kuo TC, Lee PC and Chen WY* “Salt bridge exchange binding mechanism between streptavidin and its DNA aptamer – thermodynamics and spectroscopic evidences” J. Molecular Recognition, 26, 149-159 (2013) (SCI)

  23. Lin SF, Wang CM, Tsai YL, Ding TJ, Yang TH, Chen WY, Yeh S F and Chang JY, “A model for fast predicting and optimizing the sensitivity of surface-relief guided mode resonance sensors”, Sensors and Actuator B, 176, 1197-1203 (2013) (SCI)

  24. Chen SK, Chung CA, Cheng YC, Huang CJ, Ruaan RC, Chen WY, Li Chuan, Tsao CW, Hu WW, and Chien CC “Hydrostatic pressure enhances mitomycin C- induced apoptosis in urothelial carcinoma cells” Urologic Oncology, 32(1), 17-24 (2012)

  25. Tsai CW, Kao WH, Chang LC, Ruaan RC, and Chen WY*, “Structural Stability-Chromatographic Retention Relationship on Exenatide Diastereomers Separation”, Analytical and Bioanalytical Chemistry 404(8), 2437-44. (2012)  (SCI)

  26. Tsai CW, Chen WY*, Ruaan RC* “Retention Prediction of Peptide Enantiomers in Reversed-Phase Liquid Chromatography Assisted by Molecular Dynamics Simulation” Langmuir, 2012 (Accepted) (SCI)

  27. Hu WW, Syu WJ, Chen WY, Ruaan RC, Cheng YC, Chien CC, Li C, Chung CA, and Tsao CW “Use of Biotinylated Chitosan for Substrate-Mediated Gene Delivery” Bioconjugate Chemistry 15;23(8), 1587-99. (2012) (SCI)

  28. Tsai MC, Wu JY, Lin HC, Chen TH, Hsieh YH, Shih CM, Chen WY, Huang RN and Kuo TC* “The use of a kinesin-cro fusion protein as the nano shuttle to transport specific DNA” Current Nanoscience 8, 669-675(2012) (SCI)

  29. Lin SF, Chen WY*, Chang TY* “Sensitive metal layer assisted guided mode resonance biosensor with a spectrum inversed response and strong asymmetric resonance field distribution” Optics Express, 20, 14584-14595, 2012 (SCI)

  30. Chang Y, Chang Y, Higuchi A, Shih YJ, Li PT, Chen WY, Tasi EM and Hsiue GH “Bioadhesive control of plasma proteins and blood cells from umbilical cord blood onto the interface grafted with zwitterionic polymer brushes” Langmuir, 28(9), 4309-4317, 2012 (SCI)

  31. Lin PH, Tsai CW, Wu J.W., Ruaan RC, and Chen WY*, “Molecular Dynamics Simulation of Induced-Fit Binding Process of DNA Aptamer and L-Argininamide”, Biotechnology Journal, 7, 1367–1375, 2012 (SCI)

  32. Tsao CW, Lin CH, Cheng YC, Chien CC, Chang CC and Chen WY* “Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry” Analyst, 137 (11), 2643 – 2650 (2012) (SCI)

  33. Chiang YC, Chang Y, Chen WY, and Ruaan RC, “Biofouling Resistance of Ultrafiltration Membranes Controlled by Surface Self-Assembled Coating with PEGylated Copolymers”, Langmuir 28, 1399-1407 (2012) (SCI)

  34. Hu WP, Huang LY, Kuo TC, Hu WW, Chang Y, Chen CS, Chen HC, Chen WY*      “Optimization of DNA Directed Immobilization on Mixed oligo (ethylene glycol) (OEG) Monolayers for Immunodetection”, Analytical Biochemistry 423, 26–35 (2012) (SCI)

  35. Cheng YC, Chen KH, Wang JS, Hsu WL, Chien CC, Chen WY, and Tsao CW, “Rapid Analysis of Abused Drugs Using Nanostructured Silicon Surface Assisted Laser Desorption/Ionization Mass Spectrometry”, Analyst 137 (3), 654-661 (2012) (SCI)

  36. Chen WY, Huang JT, Cheng YC, Chien CC, and Tsao CW, “Fabrication of nanostructured silicon by metal-assistend etching and its effects on matrix-free laser desorption/ionization mass spectrometry”, Analytical Chimica Acta, 687, 97-104, (2011) (SCI)

  37. Wang SSS, Lin MS, Fang YH, Lee KW, Chen SL, and Chen WY*, “Using isothermal titration calorimetry to real-time monitor the heat of metabolism: a case study using PC12 cells and Aβ (1-40)”, Colloid and Surface B: Biointerface, 83, 307-312, (2011) (SCI)

  38. Liu JT, Lin PS, Hsin YM, Tsai JZ, Chen WY “Surface plasmon resonance biosensor for microalbumin detection” Journal of the Taiwan Institute of Chemical Engineers, 42, 696-700 (2011) (SCI)

  39. Lin SF, Ding TJ, Liu JT, Lee CC, Yang TH, Chen WY* and Chang JY* “A Guided Mode Resonance Aptasensor for Thrombin Detection” Sensors 11, 8953-8965 (2011) (SCI)

  40. Higuchi, A, Lee JH, Wang Y, Chen WY, Ling QD, and Chang Y “Evaluation of bioactivity and effect of polymeric stabilizers during heat treatment for the unfolded fraction of human epidermal growth factor” Sen’I Gakkaishi, 67(8), 185-191, 2011 (SCI)

  41. Lue JH, Ding TJ, Yang TH, Chang JY, and Chen WY “Real-time Monitoring on Peptide Synthesis by GMR Biosensors” Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 4, 1858-1861 (2011) (SCI)

  42. Tsai, J.-Z., Chen, C.-J., Liu, J.-T., Hsin, Y.-M., Chen, WY, Hsueh, K.-H. “Development of capacitance measurement system for human serum albumin detection” Electronics Letters 46 (10) , 678-680 (2010)

  43. Huang HI, Cheng YC, Chen WY, Tsao CW, Huang CJ, Liu HT, and Chien CC*, “Comparative proteomic analysis of Placenta-Derived Multipotent Cells (PDMCs) and its differentiated Neuron”, The Chinese Journal of Pain, 20, 1-11, (2010) (SCI)

  44. Lin PH, Kao YH, Chang Y, Cheng YC, Chien CC, and Chen WY*, “Daunomycin interaction with DNA: Microcalorimetric studies of the thermodynamics and binding mechanism”, Biotechnology Journal, 5, 1069-1077, (2010) (SCI)

  45. Chang Y*, Yandi W, Chen WY, Shih YJ, Yang CS, Chang Y, Ling QD, and Higuchi A, “Tunable Bioadhesive copolymer hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine”, Biomacromolecules, 11, 1101-1110, (2010) (SCI)

  46. Hung YT, Lin MS, Chen WY, and Wang SSS*, “Investigating the Effects of Sodium Dodecyl Sulfate on the Aggregative Behavior of Hen Egg-White Lysozyme at Acidic pH”, Colloids and Surfaces B: Biointerfaces, 81, 141-151, (2010) (SCI)

  47. Higuchi A, Siao YD, Yang ST, Hsieh PV, Fukushima H, Chang Y, and Chen WY*,  “Peroxidase Activity of DNA Aptamer-Pt Complexes Prepared with Cisplatin”, Journal of Biomaterials Science: Polymer Edition, 21, 67-82, (2010) (SCI)

  48. Chang Y, Shu SH, Shih YJ, Chu CW, Ruaan RC, and Chen WY*, “Hemocompatible Mixed-Charge Copolymer Brushes of Pseudozwitterionic Surfaces Resistant to Nonspecific Plasma Protein Fouling”, Langmuir, 26, 3522–3530, (2010) (SCI)

  49. Roselin LS, Lin MS, Lin PH, Chang Y, and Chen WY*, “Recent trends and some applications of Isothermal Titration Calorimetry in Biotechnology”, Biotechnology Journal, 5, 85-98, (2010) (SCI)

  50. Chang Y*, Chu WL, Chen WY, Zheng J, Liu L, Ruaan RC, and Higuchi A, “A systematic SPR study of human plasma protein adsorption behavior on the controlled surface packing of self-assembled poly(ethylene oxide) triblock copolymer surfaces”, Journal of Biomedical Materials Research: Part A, 93, 400-408, (2010) (SCI)

  51. Higuchi A*, Yang ST, Li PT, Ruaan RC, Chen WY, Chang Y, Chang Y, Tasi EM, Chen YH, Wang HC, Hsu ST, and Ling QD, “Permeation of blood cells from umbilical cord blood through surface-modified polyurethane foaming membranes”, Journal of Membrane Science, 339, 184-188, (2009) (SCI)

  52. Chang Y*, Chen WY, Yandi W, Shih YJ, Chu WL, Liu YL, Ruaan RC, and Higuchi A, “Dual-Thermoresponsive Phase Behavior of Blood Compatible Zwitterionic Copolymers Containing Nonionic Poly(N-isopropyl acrylamide)”, Biomacromolecules, 10, 2092-2100, (2009) (SCI)

  53. Chiang YC, Chang Y*, Higuchi A, Chen WY, and Ruaan RC*, “Sulfobetaine-grafted poly(vinylidene fluoride) ultrafiltration membranes exhibit excellent antifouling property”, Journal of Membrane Science, 339, 151-159, (2009) (SCI)

  54. Higuchi A*, Yang ST, Li PT, Chen H, Ruaan RC, Chen WY, Chang Y, Chang Y, Tsai EM, Wang HC, and Shih-Tien Hsu, “Separation of Hematopoietic Stem and Progenitor Cells from Human Peripheral Blood Through Polyurethane Foaming Membranes Modified with Several Amino Acids”, Journal of Applied Polymer Science, 144, 671-679, (2009) (SCI)

  55. Lin PH, Tong SJ, Louis SR, Chang Y, and Chen WY*, “Thermodynamic basis of chiral recognition in a DNA aptamer”, Physical Chemistry Chemical Physics, 11, 9744-9750, (2009) (SCI)

  56. Tasi JZ, Chen CJ, Chen WY, Liu JT, Liao CY, and Hsin YM*, “A new PZT piezoelectric sensor for gravimetric applications using the resonance-frequency detection”, Sensors & Actuators B:  Chemical, 139, 259-264, (2009) (SCI)

  57. Lin MS, Chen XB, Wang SSS, Higuchi A, Chang Y, and Chen WY*, “Dynamic fluorescence imaging analysis to investigate the cholesterol recruitment in lipid monolayer during the interaction between beta-amyloid (1-40) and lipid monolayers”, Colloid and Surface B, 74, 59-66, (2009) (SCI)

  58. Higuchi A, Yang ST, Siao YD, Hsieh PV, Fukushina H, Chang Y, and Chen WY*, “Preparation of fractioned DNA aptamer–Pt complex through ultrafiltration and the colorimetric sensing of thrombin”, Journal of Membrane Science, 328, 97-103, (2009) (SCI)

  59. Higuchi A, Siao YD, Yang ST, Hsieh PV, Fukushima H, Chang Y, Ruaan RC, and Chen WY*, “Preparation of a DNA aptamer-Pt complex and its use in the colorimetric sensing of thrombin and anti-thrombin antibodies”, Analytical Chemistry, 80, 6580-6586, (2008) (SCI)

  60. Lin PH, Yen SL, Lin MS, Chang Y, Louis SR, Higuchi Akon, and Chen WY*, “Microcalorimetrics Studies of the Thermodynamics and Binding Mechanism between l-Tyrosinamide and Aptamer”, Journal of Physical and Chemistry B, 112, 6665-6673, (2008) (SCI)

  61. Lin MS, Tsai HT, Wang SSS, Chang Y, and Chen WY*, “Investigation of the mechanism of beta-amyloid fibril formation by kinetic and thermodynamic analyses”, Langmuir, 24, 5802-5808, (2008) (SCI)

  62. Chang Y*, Shih YJ, Ruaan RC, Higuchi A, Chen WY, and Lai JY, “Preparation of poly(vinylidene fluoride) microfiltration membrane with uniform surface-copolymerized poly(ethylene glycol) methacrylate and improvement of blood compatibility”, Journal of Membrane Science, 309, 165-174, 2008, (SCI)

  63. Higuchi A*, Chen WY, Yamamoto T, Gomei Y, Fukushima H, Chang Y, and Ruaan RC, “Preservation of Hematopoietic Stem and Progenitor Cells from Umbilical Cord Blood Stored in a Surface Derivatized with Polymer Nanosegments”, Biomacromolecules, 9, 634-639, (2008) (SCI)

  64. Liu JT, Chen LY, Shih MC, Chang Y, and Chen WY*, “The investigation of recognition interaction between phenylboronate monolayer and glycated hemoglobin using surface plasmon resonance”, Analytical Biochemistry, 375, 90-96, (2008) (SCI)

  65. Chang Y, Liao SC, Higuchi A, Ruaan RC, Chu CW, and Chen WY*, “A Highly Stable Nonbiofouling Surface with Well-Packed Grafted Zwitterionic Polysulfobetaine for Plasma Protein Repulsion”, Langmuir, 24, 5453-5458, (2008) (SCI)

  66. Lin MS, Tsai HT, Wang SSS, Chang Y, and Chen WY*, “Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide”, Colloids and Surfaces B: Biointerfaces, 65, 172-177, (2008) (SCI)

  67. Higuchi A*, Sekiya M, Gomei Y, Sakurai M, Chen WY, Egashira S, and Matsuoka Y, “Separation of hematopoietic stem cells from human peripheral blood through modified polyurethane foaming membranes”, Journal of Biomedical Materials Research: Part A, 85, 853-861, (2008) (SCI)

  68. Chen WY*, Liu ZC, Lin PH, Fang CI, and Yamamoto S, “The Hydrophobic Interactions of the Ion-exchanger Resin Ligands with Proteins at High Salt Concentrations by Adsorption Isotherms and Isothermal Titration Calorimetry”, Separation and Purification Technology, 54, 212-219, (2007) (SCI)

  69. Chen WY*, Lin MS, Tasi PS, Liu JT, Lin PH, and Yamamoto S, “Studies of the Interaction Mechanism between single strand and double strand DNA with Hydroxyapatite by Microcalorimetry and Isotherm Measurements”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 295, 274-283, (2007) (SCI)

  70. Chen LY, Lin JJ, Chiu SM, and Chen WY*, “Kinetics and Morphology Analysis of the Effects of Lipid Composition on Fabrication a Mimetic Bio-Membrane on Brij-76 Derived Surface”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 296, 86-91, (2007) (SCI)

  71. Chen WY, Hu WP, Su YD, Taylor A, Jiang S, and Chang GL*, “A multispot DNA chip fabricated with mixed ssDNA/Oligo (ethylene glycol) self-assembled monolayers for detecting the effect of secondary structures on hybridization by SPR imaging”, Sensor and Actuator B: Chemical, 125, 607-614, (2007) (SCI)

  72. Lin MS, Chiu HM, Fan FJ, Tsai HT, Wang SSS, Chang Y, and Chen WY*, “Kinetics and Enthalpy Measurements of Interaction between β-amyloid and Liposomes by Surface Plasmon Resonance and Isothermal Titration Microcalorimetry”, Colloids and Surfaces B: Biointerfaces, 58, 231-236, (2007) (SCI)

  73. Matsuoka Y, Onodera T, Kojima T, Chen WY, Imanaka T, Fukushima H and Higuchi A*, “Novel enzymatic properties of DNA-Pt complexes”, Biomacromolecules, 8, 2684-2688, (2007) (SCI)

  74. Lin YM, Liu HL*, Zhao JH, Huang CH, Fang HW, Ho Y, and Chen WY, “Molecular Dynamics Simulations to Investigate the Domain Swapping Mechanism of Human Cystatin C”, Biotechnology Progress, 23, 577-584, (2007) (SCI)

  75. Chen LY, Cheng CW, Lin JJ, and Chen WY*, “Exploring the effect of cholesterol in lipid bilayer membrane on the melittin penetration mechanism”, Analytical Biochemistry, 367, 49–55, (2007) (SCI)

  76. Liu HL*, Lin YM, Zhao JH, Hsieh MC, Lin HY, Huang CH, Fang HW, Ho Y, and Chen WY, “Molecular Dynamics Simulations of Human Cystatin C and Its L68Q Varient to Investigate the Domain Swapping Mechanism”, Journal Biomolecular Structure and Dynamics, 25, 135-144, (2007) (SCI)

  77. Higuchi A*, Watanabe T, Noguchi Y, Chang Y, Chen WY, and Matsuoka Y, “Visible light regulates neurite outgrowth of nerve cells”, Cytotechnology, 54, 181-188, (2007) (SCI)

  78. Chern CS*, Chen WY, Chiu HC, Chang FH, Hsieh MH, and Tu JR, “Interactions between amphiphilic graft copolymer-intercalated liposomes”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 277, 44-51, (2006) (SCI)

  79. Lin CH, Hunag CF, Chen WY, Chang YY, Ding WH, Lin MS, Wu SH, and Huang RN*, “Characterization of the Interaction of Galectin-1 with Sodium Arsenite”, Chemical Research in Toxicology, 19, 469-474, (2006) (SCI)

  80. Chen LY, Wu MC, Chou MT, Kao LA, Chen SJ, and Chen WY*, “Effects of solute-matrix interaction on monitoring the conformational changes of immobilized proteins by surface plasmon resonance sensor”, Talanta, 67, 862-867, (2005) (SCI)

  81. Liu CI, Chan YC, Chen WY, and Ruaan RC, “Effect of Amino Acid Sequence on the Hydrophobicity of Small Peptides”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 266, 175-180, (2005) (SCI)

  82. Liu AC, Chen LY, Chiou CF, Su HJ, Chan YC, Tasi PH, Chen SJ, and Chen WY*, “Thermodynamics and Mechanism of ssDNA Hybridization below the melting temperature by Isothermal Titration Calorimetry”, Thermochimica Acta, 433, 83-87. (2005) (SCI)

  83. Chang SH, Chen LY, and Chen WY*, “The Effects of Denaturants on Protein Conformation and Behavior at Air/Solution Interface”, Colloids and Surfaces B: Biointerfaces, 41, 1-6, (2005) (SCI)

  84. Chien FC, Liu JS, Su HJ, Kao LA, Chiou CF, Chen WY, and Chen SJ*, “An Investigation into the Influence of Secondary Structure on the DNA hybridization using Surface Plasmon Resonance (SPR)”, Chemical Physics Letters, 397, 429-434, (2004) (SCI)

  85. Chang RS*, Lee DY, Chen WY, Huang RN, Huang HY, Hsu JH, and Lin PL, “Method for producing coded micro-carrier and test method by using a novel type biochip”, Journal of Biotechnology, 108, 1-9, (2004) (SCI)

  86. Hu WP, Chen SJ*, Huang KT, Hsu JH, Chen WY, Chang GL, and Lai KA, “A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film”, Biosensors & Bioelectronics, 19, 1465-1471, (2004) (SCI)

  87. Liu DZ*, Hsieh YL, Chang SY, and Chen WY, “Microcalorimetric Studies on the Physical Stability of Polyethylene Glycol-Grafted Liposome”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 212, 227-234, (2003) (SCI)

  88. Tasi LM, Liu DR, and Chen WY*, “Microcalorimetric Investigation of the Interaction of Polysorbate Surfactants with Unilamellar Phosphatidylcholine Liposomes”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 213, 7-14, (2003) (SCI)

  89. Huang HM, Chen WY*, and Ruaan RC, “Microcalorimetric studies of the mechanism of interaction between designed peptides and hydrophobic adsorbents”, Journal of Colloid and Interface Science, 263, 23-28, (2003) (SCI)

  90. Chen WY*, Huang HM, Lin CC, Lin FY, and Chan YC, “Effect of Temperature on Hydrophobic Interaction Between Proteins and Hydrophobic Adsorbents – Studies by Isothermal Titration Calorimetry and the van't Hoff Equation”, Langmuir, 19, 9395-9403 (2003) (SCI)

  91. Lin FY, Chen WY*, and Hearn MTW, “Thermodynamic analysis of the interaction between proteins and solid surfaces: application to liquid chromatography”, Journal of Molecular Recognition, 15, 55-93, (2002) (SCI)

  92. Tasi YS, Lin FY, and Chen WY*, and Lin CC, “Isothermal Titration Microcalorimetric Studies of the Effect of Salt Concentrations in the Interaction between Proteins and Hydrophobic Adsorbents”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 197, 111-118, (2002) (SCI)

  93. Huang HM and Chen WY*, “Modification of Methyl Methacrylate Triblock Copolymer with Chelating Agent and Its Application in Protein Affinity Coprecipitation”, Journal of the Chinese Institute of Chemical Engineers, 33, 397-405, (2002)  (SCI)

  94. Chen WY*, Chen KH, Chen H, and Ruaan RC, “Effect of Block Size and Sequence on the Micellization, Hydrophobicity, and Surface Adsorption of ABC Triblock Methacrylic Polyampholytes by Isothermal Titration Calorimetry” Journal of the Chinese Institute of Chemical Engineers, 33, 599-608, (2002) (SCI)

  95. Chen WY*, Lee YW, Lin SC, and Ho CW, “Renaturation and Interaction of Ribonuclease A with AOT Surfactant in Reverse Micelles”, Biotechnology Progress, 18, 1443-1446, (2002) (SCI)

  96. Chen WY*, Chen CS, and Lin FY, “Molecular recognition in imprinted polymers: thermodynamic investigation of analyte binding using microcalorimetry” Journal of Chromatography A, 923(1-2): 1-6. (2001) (SCI)

  97. Lin FY, Chen CS, Chen WY*, and Yamamoto S, “Microcalorimetric studies of the interaction mechanisms between proteins and Q-Sepharose at pH near the isoelectric point (pI): Effects of NaCl concentration, pH value, and temperature”, Journal of Chromatography A, 912, 281-289, (2001) (SCI)

  98. Lin FY, Chen WY*, and Chen SM, “Microcalorimetric Study of the Effect of Hexa-Histidine Tag and Denaturant on the Interaction Mechanism between Protein and Metal-Chelating Gel”, Journal of Colloid and Interface Science, 238, 333-339, (2001) (SCI)

  99. Lin FY, Chen WY*, and Hearn MTW*, “Microcalorimetric Studies on the Interaction Mechanism Between Proteins and Hydrophobic Solid Surfaces in Hydrophobic Interaction Chromatography: Effects of Salts, Hydrophobicity of the Gel and the Structure of the Proteins”, Analytical Chemistry, 73, 3875-3883, (2001) (SCI)

  100. Lin FY, Chen WY*, Huang HM, and Ruaan RC, “Microcalorimetric Studies of  Interactions between Proteins and Hydrophobic Ligands in Hydrophobic Interaction Chromatography: Effects of Ligand Chain Length, Density and the Amount of Bound Protein”, Journal of Chromatography A, 872, 37-47, (2000) (SCI)

  101. Chen WY*, Kuo CS, and Liu DZ, “Determination of the Second Virial Coefficient of the Interaction between Microemulsion Droplets by Microcalorimetry”, Langmuir, 16, 300-302, (2000) (SCI)

  102. Huang HM, Lin FY, Chen WY*, and Ruaan RC, “Isothermal Titration Microcalorimetric Studies of the Effect of Temperature on Hydrophobic Interaction between Proteins and Hydrophobic Adsorbents”, Journal of Colloid and Interface Science, 229, 600-606, (2000) (SCI)

  103. Liu DZ and Chen WY*, Tasi LM, and Yang SP, “Microcalorimetric and shear studies on the effects of cholesterol on the physical stability of lipid vesicles”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 172, 57-67, (2000) (SCI)

  104. Lin FY, Chen WY*, and Huang SY, “Selective separation of caseinophosphopeptides through immobilized metal ion affinity chromatography: effects of pH values, salt concentrations and degree of phosphorylation”, Bioprocess Engineering, 23, 467-471, (2000) (SCI)

  105. Liu DZ, Chen WY*, Tsai LM, and Yang SP, “The Effects of Cholesterol on the Release of Free Lipids and the Physical Stability of Lecithin Liposomes”, Journal of the Chinese Institute of Chemical Engineers, 31, 269-276, (2000) (SCI)

  106. Chen WY*, Kuo CS, and Liu DZ, “A novel method of determining the aggregation behavior of microemulsion droplets”, Progress in Biotechnology, 16, 137-141, (2000) (SCI)

  107. Lin FY, Chen WY*, Ruaan RC, and Huang HM, “Microcalorimetric studies of interactions between proteins and hydrophobic ligands in hydrophobic interaction chromatography: effects of ligand chain length, density, and the amount of bound protein”, Progress in Biotechnology, 16, 59-62, (2000) (SCI)

  108. Chen WY*, Kuo CS, and Liu DZ, “Microcalorimetric and Conductivity Studies of the Effects of Solutes on the Percolation Behavior of Reverse Micelle Systems”, Journal of the Chinese Institute of Chemical Engineers, 31, 455-464, (2000) (SCI)

  109. Chen WY*, Dai KC, Ho KC, Lin FY, Huang HM, and Ruaan RC,” Application of Steric-Mass Action Model to Triblock Copolymer as a Displacer in Ion-Exchange Displacement Chromatography”, Journal of the Chinese Institute of Chemical Engineers, 30, 375-382, (1999) (SCI)

  110. Lin FY, Chen WY*, and Sang LC, “Microcalorimetric Studies of the Interactions of Lysozyme with Immobilized Metal Ions: Effects of Ion, pH Value and Salt Concentration”, Journal of Colloid and Interface Science, 214, 373-379, (1999) (SCI)

  111. Lin RY, Chen WY*, and Liao CW, “Entropy-Driven Binding/Partition of Amino Acids/Dipeptides to Stratum Corneum lipid Vesicles”, Journal of Controlled Released, 50, 51-59, (1998) (SCI)

  112. Ruaan RC*, Hsu D, Chen WY, Chen H, and Lin MS, “Protein Separation by Hydrophobic Interaction Chromatography using Methacrylic Block Copolymers as Displacers”, Journal of Chromatography A, 824, 35-43, (1998) (SCI)

  113. Lin RY, Ou YC, and Chen WY*, “The Role of Electroosmotic Flow n In-Vitro Transdermal Iontophoresis”, Journal of Controlled Release, 43, 23-33, (1997) (SCI)

  114. Chen WY*, Lee JF, and Wu CF, and Tsao HK, “Microcalorimetric Studies of the Interactions of Lysozyme with Immobilized Cu(II): Effects of pH Value and Salt Concentration”, Journal of Colloid and Interface Science, 190, 49-54, (1997) (SCI)

  115. Sung HW, Chen WY*, Tsai CC, and Hsu HL, “In vitro study of enzymatic degradation of biological tissues fixed by glutaraldehyde or epoxy compound”, Journal of Biomaterials Science: Polymer Edition, 8, 587-600, (1997) (SCI)

  116. Lin RY, Hsu CW, and Chen WY*, “A Method to Predict the Transdermal Permeability of Amino Acids and Dipeptides through Porcine Skin”, Journal of Controlled Release, 38, 229-234, (1996) (SCI)

  117. Chen WY*, Wu CF, and Liu CC, “Interactions of Imidazole and Proteins with Immobilized Cu(II) Ions: Effects of Structure, Salt Concentrations and pH in Affinity and Binding Capacity”, Journal of Colloid and Interface Science, 180, 135-143. (1996) (SCI)

  118. Wu CF, Chen WY*, and Lee JF, “Microcalorimetric Studies of the Interactions of Imidazole with Immobilized Cu(II): Effects of pH Value and Salt Concentration”, Journal of Colloid and Interface Science, 183, 236-242, (1996) (SCI)

  119. Chen FY, Chen WY*, and Kuo CS, “Protein Effect on the Bounded Water of Reverse Micelles”, Journal of the Chinese Institute of Chemical Engineers, 27, 347-351, (1996) (SCI)

  120. Lin RY, Chen WY*, and Jiang TS, “In Vitro Iontrophoretic Absorption of Angiotensin II and Antagonists by Porcine Skin”, Journal of Chinese Institute of Chemical Engineers, 26, 137-145, (1995) (SCI)

  121. Liu HS*, Wang YC, and Chen WY, “The sorption of lysozyme and ribonuclease onto ferromagnetic nickel powder 1. Adsorption of single components”, Colloids and Surfaces B: Biointerfaces, 5, 25-34, (1995) (SCI)

  122. Chen WY*, Wang LK, and Wu CF, “Calculation of Relative Binding of Free Energy of Vancomycin with Diacetyl-L-Lysyl-D-Alanyl-D-Alanine and Diacetyl-L-Lysyl-L-Alanyl-L-Alanine”, Journal of Fermentation and Bioengineering, 80, 136-140, (1995) (SCI)

  123. Wu CF, Chen WY*, and Liu HS, “Determination of the Binding Constant of Imidazole and Histidine with Immobilized Cu(II) by Differential UV Spectroscopy”, Journal of Chemical Engineering of Japan, 28, 419-423, (1995) (SCI)

  124. Chen WY, Alexandrines P*, Su CK, Patrickios CS, and Hatton TA*, “Effect of Block Size and Sequence on the Micellization of ABC Triblock Methacrylic Polyampholytes”, Macromolecules, 28, 8604-8611, (1995) (SCI)

  125. Lin RY and Chen WY*, “The Biological Membrane Applications of Isothermal Titration Calorimetry”, Journal of Chinese Colloid and Interface Society, 18, 119-128, (1995) (SCI)

  126. Chen WY*, Liu PK, Wang LK, Wu CF, and Lin RY, “Designing Peptide by Molecular Recognition Theory as Affinity Adsorption Ligand for Peptide Purification in Affinity Chromatography”, Journal of the Chinese Institute of Chemical Engineers, 26, 19-26, (1995) (SCI)

  127. Chen WY*, Wang YH, and Wang LK, “The Effect of Amino Acid Sequence on the Separation of Peptide and Protein by Reversed Micelles”, Journal of Chemical Engineering of Japan, 27, 685-687, (1994) (SCI)

  128. Chen WY*, Shu CG, Chen JY, and Lee JF, “The Effect of Amino Acid Sequence on the Partition of Peptides in Aqueous Two-phase System”, Journal of Chemical Engineering of Japan, 27, 688-690, (1994) (SCI)

  129. Chen WY*, Wang YH, and Wang LK, “The Effect of Amino Acid Sequence on the Separation of Peptide and Protein by Reversed Micelles”, Journal of Chemical Engineering of Japan, 27, 685-687, (1994) (SCI)

  130. Chen WY*, Shu CG, Chen JY, and Lee JF, “The Effect of Amino Acid Sequence on the Partition of Peptides in Aqueous Two-phase System”, Journal of Chemical Engineering of Japan, 27, 688-690, (1994) (SCI)

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Other Publications:

Chen WY*, Lin SF, Chang, CY, “光學免標定式波導共振生物感測器與其應用”化工技術月刊, 2012 (六月刊)

Chen WY*, Huang LY, and Hu WP, “表面電漿共振生物感測器簡件與運用”,化工, 58 (4),3-17 (2011)

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